Genome Editing in Agriculture: Technical and Practical Considerations

Diffusion Imaging of the Brain: Technical Considerations and Practical Applications

This chapter presents a brief introduction to the application of diffusion-weighted magnetic resonance imaging (MRI) to in vivo studies. Diffusion-weighted MRI has found application both in the clinic, and in basic neuroscience. In the former situation it is primarily used for the detection of brain lesions, in particular infarcted regions. The ability to follow fibre tracts in white matter via...

CRISPR/Cas9: A Practical Approach in Date Palm Genome Editing

The genetic modifications through breeding of crop plants have long been used to improve the yield and quality. However, precise genome editing (GE) could be a very useful supplementary tool for improvement of crop plants by targeted genome modifications. Various GE techniques including ZFNs (zinc finger nucleases), TALENs (transcription activator-like effector nucleases), and most recently clu...

Advancing Chimeric Antigen Receptor-Engineered T-Cell Immunotherapy Using Genome Editing Technologies: Challenges and Future Prospects

Chimeric antigen receptor engineered-T (CAR-T) cells also named as living drugs, have been recently known as a breakthrough technology and were applied as an adoptive immunotherapy against different types of cancer. They also attracted widespread interest because of the success of B-cell malignancy therapy achieved by anti-CD19 CAR-T cells. Current genetic toolbox enabled the synthesis of CARs ...

Practical and Economic Considerations

PUBLIC LENDING RIGHT (PLR) is a right to receive payment in respect of the lending of books (or possibly other materials) to the public. T h e right, which is usually accorded by law, is most commonly thought of as being appropriate to authors, but publishers have sometimes claimed an equal interest. Lending is usually understood to mean lending for use off library premises, but use within the ...

Genome Editing